Antibacterial and Antifungal Studies on Some Schiff Base Complexes of Zinc(II)

نویسندگان

  • R. Selwin Joseyphus
  • M. Sivasankaran Nair
چکیده

Two Schiff base ligands L1and L2 were obtained by the condensation of glycylglycine respectively with imidazole-2-carboxaldehyde and indole-3-carboxaldehyde and their complexes with Zn(II) were prepared and characterized by microanalytical, conductivity measurement, IR, UV-Vis., XRD and SEM. The molar conductance measurement indicates that the Zn(II) complexes are 1: 1electrolytes. The IR data demonstrate the tetradentate binding of L1and tridentate binding of L2. The XRD data show that Zn(II) complexes with L1and L2 have the crystallite sizes of 53 and 61nm respectively. The surface morphology of the complexes was studied using SEM. The in vitro biological screening effects of the investigated compounds were tested against the bacterial species Staphylococcus aureus, Escherichia coli, Klebsiella pneumaniae, Proteus vulgaris and Pseudomonas aeruginosa and fungal species Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by the disc diffusion method. A comparative study of inhibition values of the Schiff base ligands and their complexes indicates that the complexes exhibit higher antimicrobial activity than the free ligands. Zinc ions are proven to be essential for the growth-inhibitor effect. The extent of inhibition appeared to be strongly dependent on the initial cell density and on the growth medium.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Synthesis and characterization of some transition metal complexes of Schiff base derived from 2,4 - dihydroxybenzaldehyde

Abstract New N2O2 type Schiff base has been designed and synthesized by condensing 2,4 dihydroxy benzaldehyde and α-naphthylamine in ethanol. Solid metal complexes of the schiff base with Cu(II), Ni(II) and Zn(II) metal ion were synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR, UV-Vis and ‘H NMR spectral studies. The data shows that the c...

متن کامل

Metal-Based Biologically Active Compounds: Synthesis, Spectral, and Antimicrobial Studies of Cobalt, Nickel, Copper, and Zinc Complexes of Triazole-Derived Schiff Bases

A series of cobalt, nickel, copper, and zinc complexes of bidentate Schiff bases derived from the condensation reaction of 4-amino-5-mercapto-3-methyl/ethyl-1,2,4-triazole with 2,4-dichlorobenzaldehyde were synthesized and tested as antimicrobial agents. The synthesized Schiff bases and their metal complexes were characterized with the aid of elemental analyses, magnetic moment measurements, sp...

متن کامل

Synthesis of New Schiff Base Ligand and Its Complexes in The Presence of Some Transition Metal Ion and Evaluation of Their Antibacterial Properties

ABSTRACT         Background and objectives: Synthesis and characterization of several metal complexes (metal ions: Co2+, Ti4+ and Ce3+) of macroacyclic Schiff base ligand have been reported. The Schiff base ligand is prepared from the condensation reaction of 1, 4-di-(4-fluoro-2-aminophenoxy) butane with salicylaldehyde in ethanol. In addition, antibacterial ...

متن کامل

Synthesis Characterization and Antimicrobial Activity Studies of Some Transition Metal Complexes Derived from 3-Chloro-N′-[(1E)-(2-hydroxy phenyl)methylene]-6-methoxy-1-benzothiophene-2-carbohydrazide

A series of new coordination complexes of Cu(II), Co(II), Ni(II), Zn(II), Hg(II), Mn(II), and Fe(III) with the Schiff base 3-chloro-N'-[(1E)-(2-hydroxy phenyl)methylene]-6-methoxy-1-benzothiophene-2-carbohydrazide (HL) have been synthesized and characterized by elemental analysis, electrical conductivity measurements, IR spectra, (1)H NMR, mass spectral data, electronic spectra, magnetic suscep...

متن کامل

Synthesis, Characterization and Biological Activities of a New 5-Chloroisatin Schiff Base and its Metal Complexes

Copper (II), cobalt (II), nickel (II) and zinc (II) complexes of 5-chloroisatin Schiff base (L) (L= Schiff base derived from 5-chloroisatin and 2-methyl-4nitro aniline) were synthesized and characterized. The authenticity of the ligand and its metal complexes had been established by micro analysis, IR, NMR, LC/MS, UV-Vis and electrical conductance measurements. The ligand acts as a bidentate in...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 36  شماره 

صفحات  -

تاریخ انتشار 2008